| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NAB2 |
| Gene ID: | 4665 |
| Uniprot ID: | NAB2_HUMAN |
| Immunogen Region: | 1-200 |
| Immunogen Sequence: | MHRAPSPTAEQPPGGGDSAR RTLQPRLKPSARAMALPRTL GELQLYRVLQRANLLSYYET FIQQGGDDVQQLCEAGEEEF LEIMALVGMATKPLHVRRLQ KALREWATNPGLFSQPVPAV PVSSIPLFKISETAGTRKGS MSNGHGSPGEKAGSARSFSP KSPLELGEKLSPLPGGPGAG DPRIWPGRSTPESDVGAGGE |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human NAB2 (NP_005958.1). |
| Tissue Specificity | Widely expressed at low levels. Highly expressed in melanoma cell lines. |
| Post Translational Modifications | Sumoylation by EGR2 represses EGR2 transcriptional activity in hindbrain. |
| Function | Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability. |
| Protein Name | Ngfi-A-Binding Protein 2Egr-1-Binding Protein 2Melanoma-Associated Delayed Early Response ProteinProtein Mader |
| Database Links | Reactome: R-HSA-9031628Reactome: R-HSA-9619665 |
| Cellular Localisation | NucleusIsoform 2 Is Not Localized To The Nucleus |
| Alternative Antibody Names | Anti-Ngfi-A-Binding Protein 2 antibodyAnti-Egr-1-Binding Protein 2 antibodyAnti-Melanoma-Associated Delayed Early Response Protein antibodyAnti-Protein Mader antibodyAnti-NAB2 antibodyAnti-MADER antibody |
Information sourced from Uniprot.org
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