Anti-N-Acetyl-D-Glucosamine Kinase/NAGK antibody (1-344aa) [AT4D12] (STJA0041632)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
ImmunogenRecombinant human NAGK (1-344aa) purified from E. coli
General Information
| Short Description | Mouse monoclonal anti-N-Acetyl-D-Glucosamine Kinase/NAGK (1-344aa) for use in ELISA, WB, ICC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB/ICC/IF |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | AT4D12 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | By protein-G affinity chromatography |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NAGK |
| Gene ID | 55577 |
| Uniprot ID | NAGK_HUMAN |
| Accession Number | NP_060037.2 |
| Immunogen | Recombinant human NAGK (1-344aa) purified from E. coli |
| Immunogen Region | 1-344aa |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Function | Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. Also has N-acetylmannosamine (ManNAc) kinase activity. Also involved in innate immunity by promoting detection of bacterial peptidoglycan by NOD2: acts by catalyzing phosphorylation of muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, to generate 6-O-phospho-muramyl dipeptide, which acts as a direct ligand for NOD2. |
| Protein Name | N-Acetyl-D-Glucosamine KinaseN-Acetylglucosamine KinaseGlcnac KinaseMuramyl Dipeptide KinaseN-Acetyl-D-Mannosamine Kinase |
| Database Links | Reactome: R-HSA-446210 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-N-Acetyl-D-Glucosamine Kinase antibodyAnti-N-Acetylglucosamine Kinase antibodyAnti-Glcnac Kinase antibodyAnti-Muramyl Dipeptide Kinase antibodyAnti-N-Acetyl-D-Mannosamine Kinase antibodyAnti-NAGK antibody |
Information sourced from Uniprot.org