Anti-MZB1 antibody (1-50 aa) (STJ98819)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide from the human protein at the amino acid range 1-50
General Information
| Short Description | Rabbit polyclonal anti-Marginal zone B-and B1-cell-specific protein (1-50 aa) for use in IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC-P 1:50-200ELISA 1:10000-20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MZB1 |
| Gene ID | 51237 |
| Uniprot ID | MZB1_HUMAN |
| Immunogen | Synthetic peptide from the human protein at the amino acid range 1-50 |
| Immunogen Region | 1-50 aa |
| Specificity | The antibody detects endogenous PACAP |
Additional Info
| Post Translational Modifications | Forms an interchain disulfide bond with IgM monomers. |
| Function | Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity. Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation. Acts as a hormone-regulated adipokine/pro-inflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance. |
| Protein Name | Marginal Zone B- And B1-Cell-Specific ProteinMesenteric Estrogen-Dependent Adipose 7Meda-7Plasma Cell-Induced Resident Endoplasmic Reticulum ProteinPlasma Cell-Induced Resident Er ProteinPerp1Proapoptotic Caspase Adapter Protein |
| Database Links | |
| Cellular Localisation | Isoform 1: Endoplasmic Reticulum LumenSecretedIsoform 2: CytoplasmDiffuse Granular Localization In The Cytoplasm Surrounding The Nucleus |
| Alternative Antibody Names | Anti-Marginal Zone B- And B1-Cell-Specific Protein antibodyAnti-Mesenteric Estrogen-Dependent Adipose 7 antibodyAnti-Meda-7 antibodyAnti-Plasma Cell-Induced Resident Endoplasmic Reticulum Protein antibodyAnti-Plasma Cell-Induced Resident Er Protein antibodyAnti-Perp1 antibodyAnti-Proapoptotic Caspase Adapter Protein antibodyAnti-MZB1 antibodyAnti-MEDA7 antibodyAnti-PACAP antibodyAnti-HSPC190 antibody |
Information sourced from Uniprot.org