| Tissue Specificity | Widely expressed with highest levels in adult brain, small intestine and lymphoid tissues such as thymus and spleen. Expression is frequently lower in intestinal-type gastric cancer. In obese patients, more abundant in omental than in subcutaneous fat. |
| Post Translational Modifications | Forms an interchain disulfide bond with IgM monomers. |
| Function | Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity. Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation. Acts as a hormone-regulated adipokine/pro-inflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance. |
| Protein Name | Marginal Zone B- And B1-Cell-Specific ProteinMesenteric Estrogen-Dependent Adipose 7Meda-7Plasma Cell-Induced Resident Endoplasmic Reticulum ProteinPlasma Cell-Induced Resident Er ProteinPerp1Proapoptotic Caspase Adapter Protein |
| Database Links | |
| Cellular Localisation | Isoform 1: Endoplasmic Reticulum LumenSecretedIsoform 2: CytoplasmDiffuse Granular Localization In The Cytoplasm Surrounding The Nucleus |
| Alternative Antibody Names | Anti-Marginal Zone B- And B1-Cell-Specific Protein antibodyAnti-Mesenteric Estrogen-Dependent Adipose 7 antibodyAnti-Meda-7 antibodyAnti-Plasma Cell-Induced Resident Endoplasmic Reticulum Protein antibodyAnti-Plasma Cell-Induced Resident Er Protein antibodyAnti-Perp1 antibodyAnti-Proapoptotic Caspase Adapter Protein antibodyAnti-MZB1 antibodyAnti-MEDA7 antibodyAnti-PACAP antibodyAnti-HSPC190 antibody |
Information sourced from Uniprot.org
