| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MYRF (1-100) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MYRF |
| Gene ID: |
745 |
| Uniprot ID: |
MYRF_HUMAN |
| Immunogen Region: |
1-100 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MYRF (NP_001120864.1). |
| Immunogen Sequence: |
MEVVDETEALQRFFEGHDIN GALEPSNIDTSILEEYISKE DASDLCFPDISAPASSASYS HGQPAMPGSSGVHHLSPPGG GPSPGRHGPLPPPGYGTPLN |
| Tissue Specificity | Expressed in lung, ARPE-19 cell line, brainstem, uterus and, to a lesser extent, in basal ganglion and liver. Weakly expressed in cerebellum and retina. |
| Post Translational Modifications | Myelin regulatory factor, C-terminal: Glycosylated. Myelin regulatory factor: Follows autocatalytic cleavage via the peptidase S74 domain. Autoprocessing is apparently constitutive and is essential for transcriptional activity. Autocatalytic cleavage is inhibited by interaction with TMEM98. |
| Function | Myelin regulatory factor: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes. Myelin regulatory factor, C-terminal: Membrane-bound part that has no transcription factor activity and remains attached to the endoplasmic reticulum membrane following cleavage. Myelin regulatory factor, N-terminal: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG, DUSP15 and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Specifically recognizes and binds DNA sequence 5'-CTGGYAC-3' in the regulatory regions of myelin-specific genes and directly activates their expression. Not only required during oligodendrocyte differentiation but is also required on an ongoing basis for the maintenance of expression of myelin genes and for the maintenance of a mature, viable oligodendrocyte phenotype. |
| Protein Name | Myelin Regulatory FactorMyelin Gene Regulatory Factor Cleaved Into - Myelin Regulatory Factor - N-Terminal - Myelin Regulatory Factor - C-Terminal |
| Cellular Localisation | Myelin Regulatory Factor: Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinMyelin Regulatory FactorN-Terminal: NucleusCytoplasmTranslocates From The Cytoplasm To The Nucleus Upon Autocatalytic CleavageC-Terminal: Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Myelin Regulatory Factor antibodyAnti-Myelin Gene Regulatory Factor Cleaved Into - Myelin Regulatory Factor - N-Terminal - Myelin Regulatory Factor - C-Terminal antibodyAnti-MYRF antibodyAnti-C11orf9 antibodyAnti-KIAA0954 antibodyAnti-MRF antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
