| Short Description : | Rabbit polyclonal MYO1D (180-380) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MYO1D |
| Gene ID: | 4642 |
| Uniprot ID: | MYO1D_HUMAN |
| Immunogen Region: | 180-380 |
| Immunogen Sequence: | HINNYLLEKSRVIVQQPGER SFHSFYQLLQGGSEQMLRSL HLQKSLSSYNYIHVGAQLKS SINDAAEFRVVADAMKVIGF KPEEIQTVYKILAAILHLGN LKFVVDGDTPLIENGKVVSI IAELLSTKTDMVEKALLYRT VATGRDIIDKQHTEQEASYG RDAFAKAIYERLFCWIVTRI NDIIEVKNYDTTIHGKNTVI G |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 180-380 of human MYO1D (NP_001290209.1). |
| Tissue Specificity | Expressed in many tissues. Highest levels in brain, followed by lung and ovary.expression is lowest in spleen. |
| Function | Unconventional myosin that functions as actin-based motor protein with ATPase activity. Plays a role in endosomal protein trafficking, and especially in the transfer of cargo proteins from early to recycling endosomes. Required for normal planar cell polarity in ciliated tracheal cells, for normal rotational polarity of cilia, and for coordinated, unidirectional ciliary movement in the trachea. Required for normal, polarized cilia organization in brain ependymal epithelial cells. |
| Protein Name | Unconventional Myosin-Id |
| Database Links | |
| Cellular Localisation | CytoplasmPerikaryonCell ProjectionDendriteEarly EndosomeCell CortexColocalizes With The Actin Cytoskeleton In The Cell Cortex Close To The Apical Cell MembraneColocalizes With Cytoplasmic Puncta That Are Reminiscent Of Transport Vesicles |
| Alternative Antibody Names | Anti-Unconventional Myosin-Id antibodyAnti-MYO1D antibodyAnti-KIAA0727 antibody |
Information sourced from Uniprot.org
