| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MYO10 (845-944) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MYO10 |
| Gene ID: |
4651 |
| Uniprot ID: |
MYO10_HUMAN |
| Immunogen Region: |
845-944 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 845-944 of human MYO10 (NP_036466.2). |
| Immunogen Sequence: |
EAELRAQQEEETRKQQELEA LQKSQKEAELTRELEKQKEN KQVEEILRLEKEIEDLQRMK EQQELSLTEASLQKLQERRD QELRRLEEEACRAAQEFLES |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | The initiator methionine for isoform Headless is removed. |
| Function | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as a plus end-directed motor. Moves with higher velocity and takes larger steps on actin bundles than on single actin filaments. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation. Plays a role in formation of the podosome belt in osteoclasts. Isoform Headless: Functions as a dominant-negative regulator of isoform 1, suppressing its filopodia-inducing and axon outgrowth-promoting activities. In hippocampal neurons, it increases VASP retention in spine heads to induce spine formation and spine head expansion. |
| Protein Name | Unconventional Myosin-XUnconventional Myosin-10 |
| Database Links | Reactome: R-HSA-2029482Reactome: R-HSA-373752Reactome: R-HSA-9664422 |
| Cellular Localisation | CytoplasmCytosolCell ProjectionLamellipodiumRuffleCytoskeletonFilopodium TipCell CortexFilopodium MembranePeripheral Membrane ProteinMay Be In An InactiveMonomeric Conformation In The CytosolDetected In Cytoplasmic Punctae And In Cell ProjectionsColocalizes With Actin FibersUndergoes Forward And Rearward Movements Within FilopodiaInteracts With Microtubules |
| Alternative Antibody Names | Anti-Unconventional Myosin-X antibodyAnti-Unconventional Myosin-10 antibodyAnti-MYO10 antibodyAnti-KIAA0799 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
