| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MYLIP (266-445) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MYLIP |
| Gene ID: |
29116 |
| Uniprot ID: |
MYLIP_HUMAN |
| Immunogen Region: |
266-445 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 266-445 of human MYLIP (NP_037394.2). |
| Immunogen Sequence: |
RAITETHAFYRCDTVTSAVM MQYSRDLKGHLASLFLNENI NLGKKYVFDIKRTSKEVYDH ARRALYNAGVVDLVSRNNQS PSHSPLKSSESSMNCSSCEG LSCQQTRVLQEKLRKLKEAM LCMVCCEEEINSTFCPCGHT VCCESCAAQLQSCPVCRSRV EHVQHVYLPTHTSLLNLTVI |
| Tissue Specificity | Ubiquitously expressed. |
| Post Translational Modifications | Autoubiquitinated. |
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR. |
| Protein Name | E3 Ubiquitin-Protein Ligase MylipInducible Degrader Of The Ldl-ReceptorIdolMyosin Regulatory Light Chain Interacting ProteinMirRing-Type E3 Ubiquitin Transferase Mylip |
| Database Links | Reactome: R-HSA-8866427Reactome: R-HSA-9031525Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Mylip antibodyAnti-Inducible Degrader Of The Ldl-Receptor antibodyAnti-Idol antibodyAnti-Myosin Regulatory Light Chain Interacting Protein antibodyAnti-Mir antibodyAnti-Ring-Type E3 Ubiquitin Transferase Mylip antibodyAnti-MYLIP antibodyAnti-BZF1 antibodyAnti-IDOL antibodyAnti-BM-023 antibodyAnti-PP5242 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
