Anti-MYL12B antibody [R14-2G-3] (STJA0035573)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human MYL12B
General Information
| Short Description | Rabbit monoclonal anti-MYL12B for use in WB, IHC-P, ICC and IF in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ICC/IF |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R14-2G-3 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IHC 1:100-1:200IF 1:50-1:200 |
| Formulation | Liquid in PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | MYL12B |
| Gene ID | 103910 |
| Uniprot ID | ML12B_HUMAN |
| Immunogen | A synthesized peptide derived from human MYL12B |
Additional Info
| Tissue Specificity | Ubiquitously expressed in various hematopoietic cells. |
| Post Translational Modifications | Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge. Phosphorylation is reduced following epigallocatechin-3-O-gallate treatment. |
| Function | Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion. |
| Protein Name | Myosin Regulatory Light Chain 12bMlc-2aMlc-2Myosin Regulatory Light Chain 2-B - Smooth Muscle IsoformMyosin Regulatory Light Chain 20 KdaMlc20Myosin Regulatory Light Chain Mrlc2Shujun-1 |
| Database Links | Reactome: R-HSA-3928663Reactome: R-HSA-416572Reactome: R-HSA-445355Reactome: R-HSA-5625740Reactome: R-HSA-5625900Reactome: R-HSA-5627117Reactome: R-HSA-5627123 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Myosin Regulatory Light Chain 12b antibodyAnti-Mlc-2a antibodyAnti-Mlc-2 antibodyAnti-Myosin Regulatory Light Chain 2-B - Smooth Muscle Isoform antibodyAnti-Myosin Regulatory Light Chain 20 Kda antibodyAnti-Mlc20 antibodyAnti-Myosin Regulatory Light Chain Mrlc2 antibodyAnti-Shujun-1 antibodyAnti-MYL12B antibodyAnti-MRLC2 antibodyAnti-MYLC2B antibody |
Information sourced from Uniprot.org