Anti-Myd88 antibody [603E10.06] (STJ16102443)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
General Information
| Short Description | Mouse monoclonal anti-Myd88 for use in IF in Human, Dog and Pig samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF |
| Host | Mouse |
| Reactivity | Human/Dog/Pig |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 603E10.06 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Purified |
| Formulation | TRIS, PBS, pH7 and antibiotics |
| Storage Instruction | Store at-20ยฐC for up to 1 year. |
Target Information
| Gene Symbol | Myd88 |
| Gene ID | 17874 |
| Uniprot ID | MYD88_MOUSE |
Additional Info
| Post Translational Modifications | Ubiquitinated.undergoes 'Lys-63'-linked polyubiquitination. OTUD4 specifically hydrolyzes 'Lys-63'-linked polyubiquitinated MYD88. Deubiquitinated by USP3 that cleaves 'Lys-63'-linked ubiquitin chains leading to inhibition of MYD88-induced NF-kappa-B signaling. |
| Function | Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses, induces IL1B release through NLRP3 inflammasome activation. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine. Mediates leukocyte recruitment at the inflammatory site. Isoform 2: Defective in its ability to induce IRAK phosphorylation and NF-kappa-B activation and can function as a negative regulator of activation by IL-1 or lipopolysaccharide (LPS). |
| Protein Name | Myeloid Differentiation Primary Response Protein Myd88 |
| Database Links | Reactome: R-MMU-1257604Reactome: -MMU-1810476Reactome: -MMU-209543Reactome: -MMU-3134963Reactome: -MMU-6811558Reactome: -MMU-9020702 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Myeloid Differentiation Primary Response Protein Myd88 antibodyAnti-Myd88 antibody |
Information sourced from Uniprot.org