| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MXD1 (100-200) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MXD1 |
| Gene ID: |
4084 |
| Uniprot ID: |
MAD1_HUMAN |
| Immunogen Region: |
100-200 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human MXD1 (NP_002348.1). |
| Immunogen Sequence: |
KAKLHIKKLEDCDRKAVHQI DQLQREQRHLKRQLEKLGIE RIRMDSIGSTVSSERSDSDR EEIDVDVESTDYLTGDLDWS SSSVSDSDERGSMQSLGSDE G |
| Post Translational Modifications | Ubiquitinated by BIRC2/c-IAP1, leading to its subsequent degradation by the proteasome. |
| Function | Component of a transcriptional repressor complex together with MAX. In complex with MAX binds to the core DNA sequence 5'-CACGATG-3'. Antagonizes MYC transcriptional activity by competing with MYC for MAX binding. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding. |
| Protein Name | Max Dimerization Protein 1Max Dimerizer 1Protein Mad |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Max Dimerization Protein 1 antibodyAnti-Max Dimerizer 1 antibodyAnti-Protein Mad antibodyAnti-MXD1 antibodyAnti-MAD antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
