| Host: |
Rabbit |
| Applications: |
WB/IHC/IF |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MX1 (200-300) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IHC-P 1:50-1:200IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MX1 |
| Gene ID: |
4599 |
| Uniprot ID: |
MX1_HUMAN |
| Immunogen Region: |
200-300 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 200-300 of human MX1 (NP_001171517.1). |
| Immunogen Sequence: |
TLIKKYIQRQETISLVVVPS NVDIATTEALSMAQEVDPEG DRTIGILTKPDLVDKGTEDK VVDVVRNLVFHLKKGYMIVK CRGQQEIQDQLSLSEALQRE K |
| Post Translational Modifications | ISGylated. |
| Function | Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs. |
| Protein Name | Interferon-Induced Gtp-Binding Protein Mx1Interferon-Induced Protein P78Ifi-78kInterferon-Regulated Resistance Gtp-Binding Protein MxaMyxoma Resistance Protein 1Myxovirus Resistance Protein 1 Cleaved Into - Interferon-Induced Gtp-Binding Protein Mx1 - N-Terminally Processed |
| Database Links | Reactome: R-HSA-1169408Reactome: R-HSA-909733 |
| Cellular Localisation | CytoplasmEndoplasmic Reticulum MembranePeripheral Membrane ProteinCytoplasmic SidePerinuclear RegionBinds Preferentially To Negatively Charged PhospholipidsColocalizes With Cchfv Protein N In The Perinuclear RegionIsoform 2: CytoplasmNucleusTranslocates Into The Nuclei Of Hsv-1 Infected Cells |
| Alternative Antibody Names | Anti-Interferon-Induced Gtp-Binding Protein Mx1 antibodyAnti-Interferon-Induced Protein P78 antibodyAnti-Ifi-78k antibodyAnti-Interferon-Regulated Resistance Gtp-Binding Protein Mxa antibodyAnti-Myxoma Resistance Protein 1 antibodyAnti-Myxovirus Resistance Protein 1 Cleaved Into - Interferon-Induced Gtp-Binding Protein Mx1 - N-Terminally Processed antibodyAnti-MX1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
