Anti-MVP antibody (STJ192985)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Major vault protein for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MVP |
| Gene ID | 9961 |
| Uniprot ID | MVP_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | MVP Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Phosphorylated on Tyr residues after EGF stimulation. Dephosphorylated by PTPN11. |
| Function | Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. |
| Protein Name | Major Vault ProteinMvpLung Resistance-Related Protein |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | CytoplasmNucleusNuclear Pore ComplexPerinuclear Region5% Found In The Nuclear Pore ComplexTranslocates From The Nucleus To The Cytoplasm Upon Egf Treatment |
| Alternative Antibody Names | Anti-Major Vault Protein antibodyAnti-Mvp antibodyAnti-Lung Resistance-Related Protein antibodyAnti-MVP antibodyAnti-LRP antibody |
Information sourced from Uniprot.org