MUM1 antibody immunohistochemistry paraffin-embedded tonsil tissue STJA0037645

Anti-MUM1 antibody [BP6094] (STJA0037645)

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STJA0037645
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Short Description :Rabbit monoclonal anti-MUM1 for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents.
Applications:IHC-P
Host:Rabbit
Reactivity:Human
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :BP6094
Isotype:IgG
Conjugation:Unconjugated
Purification:Affinity Purified
Dilution Range:IHC 1:100-1:200
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Storage Instruction:Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles.
Gene Symbol:IRF4
Gene ID:3662
Uniprot ID:IRF4_HUMAN
Immunogen:A synthesized peptide derived from human IRF4
Tissue Specificity Lymphoid cells.
Post Translational Modifications Phosphorylation by ROCK2 regulates IL-17 and IL-21 production.
Function Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes.
Protein Name Interferon Regulatory Factor 4
Irf-4
Lymphocyte-Specific Interferon Regulatory Factor
Lsirf
Multiple Myeloma Oncogene 1
Nf-Em5
Database Links Reactome: R-HSA-6785807
Reactome: R-HSA-877300
Reactome: R-HSA-909733
Reactome: R-HSA-9725371
Reactome: R-HSA-9824585
Cellular Localisation Nucleus
Cytoplasm
Alternative Antibody Names Anti-Interferon Regulatory Factor 4 antibody
Anti-Irf-4 antibody
Anti-Lymphocyte-Specific Interferon Regulatory Factor antibody
Anti-Lsirf antibody
Anti-Multiple Myeloma Oncogene 1 antibody
Anti-Nf-Em5 antibody
Anti-IRF4 antibody
Anti-MUM1 antibody

Information sourced from Uniprot.org

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