Anti-MUL1 antibody (STJ191920)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Mitochondrial ubiquitin ligase activator of NFKB 1 for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MUL1 |
| Gene ID | 79594 |
| Uniprot ID | MUL1_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | MUL1 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. |
| Function | Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteasomal degradation. Mediates polyubiquitination of cytoplasmic TP53 at 'Lys-24' which targets TP53 for proteasomal degradation, thus reducing TP53 levels in the cytoplasm and mitochondrion. Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology by promoting mitochondrial fragmentation, and influences mitochondrial localization. Likely to promote mitochondrial fission through negatively regulating the mitochondrial fusion proteins MFN1 and MFN2, acting in a pathway that is parallel to the PRKN/PINK1 regulatory pathway. May also be involved in the sumoylation of the membrane fission protein DNM1L. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. Involved in the modulation of innate immune defense against viruses by inhibiting RIGI-dependent antiviral response. Can mediate RIGI sumoylation and disrupt its polyubiquitination. |
| Protein Name | Mitochondrial Ubiquitin Ligase Activator Of Nfkb 1E3 Sumo-Protein Ligase Mul1E3 Ubiquitin-Protein Ligase Mul1Growth Inhibition And Death E3 LigaseMitochondrial-Anchored Protein LigaseProtein HadesPutative Nf-Kappa-B-Activating Protein 266Ring Finger Protein 218Ring-Type E3 Ubiquitin Transferase Nfkb 1 |
| Database Links | Reactome: R-HSA-5689880Reactome: R-HSA-8951664Reactome: R-HSA-9755511 |
| Cellular Localisation | Mitochondrion Outer MembraneMulti-Pass Membrane ProteinPeroxisomeTransported In Mitochondrion-Derived Vesicles From The Mitochondrion To The Peroxisome |
| Alternative Antibody Names | Anti-Mitochondrial Ubiquitin Ligase Activator Of Nfkb 1 antibodyAnti-E3 Sumo-Protein Ligase Mul1 antibodyAnti-E3 Ubiquitin-Protein Ligase Mul1 antibodyAnti-Growth Inhibition And Death E3 Ligase antibodyAnti-Mitochondrial-Anchored Protein Ligase antibodyAnti-Protein Hades antibodyAnti-Putative Nf-Kappa-B-Activating Protein 266 antibodyAnti-Ring Finger Protein 218 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Nfkb 1 antibodyAnti-MUL1 antibodyAnti-C1orf166 antibodyAnti-GIDE antibodyAnti-MAPL antibodyAnti-MULAN antibodyAnti-RNF218 antibody |
Information sourced from Uniprot.org