Anti-MUC-6 antibody [ZR437] (STJ180652)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant fragment covering tandem repeats of human MUC-6 protein
General Information
| Short Description | Rabbit monoclonal MUC-6 antibody for use in IHC-P in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | ZR437 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity purified |
| Dilution Range | 1:100-200 |
| Formulation | Tris-HCI buffer containing stabilizing protein (BSA) and <0.1% ProClin |
| Storage Instruction | Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C. |
Target Information
| Gene Symbol | MUC5B |
| Gene ID | 727897 |
| Uniprot ID | MUC5B_HUMAN |
| Immunogen | Recombinant fragment covering tandem repeats of human MUC-6 protein |
| Specificity | Positive Control: Stomach |
Additional Info
| Tissue Specificity | Expressed on surface airway epithelia. Expressed mainly in mucous cells of submucosal glands of airway tissues. Highly expressed in the sublingual gland. Also found in submaxillary glands, endocervix, gall bladder, and pancreas. |
| Post Translational Modifications | Highly glycosylated. C-, N- and O-glycosylated. C-mannosylated in the Cys-rich subdomains probably on the first Trp residue of the WXXW motif. Highly O-glycosylated in the Ser/Thr-rich tandem repeat (TR) region. The repeat region is about 59% O-glycosylated with a high abundance of NeuAc(2)Hex(1)HexNac1-ol. |
| Function | Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus. |
| Protein Name | Mucin-5bMuc-5bCervical MucinHigh Molecular Weight Salivary Mucin Mg1Mucin-5 Subtype B - TracheobronchialSublingual Gland Mucin |
| Database Links | Reactome: R-HSA-5083625Reactome: R-HSA-5083632Reactome: R-HSA-5083636Reactome: R-HSA-5621480Reactome: R-HSA-913709Reactome: R-HSA-977068 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Mucin-5b antibodyAnti-Muc-5b antibodyAnti-Cervical Mucin antibodyAnti-High Molecular Weight Salivary Mucin Mg1 antibodyAnti-Mucin-5 Subtype B - Tracheobronchial antibodyAnti-Sublingual Gland Mucin antibodyAnti-MUC5B antibodyAnti-MUC5 antibody |
Information sourced from Uniprot.org