Anti-MTUS1 antibody (207-436) (STJ115398)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MTUS1 (207-436) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MTUS1 |
| Gene ID | 57509 |
| Uniprot ID | MTUS1_HUMAN |
| Immunogen Region | 207-436 |
| Immunogen Sequence | NAAHETSKLEIEASHSEKLE LLKKAYEASLSEIKKGHEIE KKSLEDLLSEKQESLEKQIN DLKSENDALNEKLKSEEQKR RAREKANLKNPQIMYLEQEL ESLKAVLEIKNEKLHQQDIK LMKMEKLVDNNTALVDKLKR FQQENEELKARMDKHMAISR QLSTEQAVLQESLEKESKVN KRLSMENEELLWKLHNGDLC SPKRSPTSSAIPLQSPRNSG SFPSPSISPR |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 207-436 of human MTUS1 (NP_065800.1). |
Additional Info
| Tissue Specificity | Ubiquitously expressed (at protein level). Highly expressed in brain. Down-regulated in ovarian carcinoma, pancreas carcinoma, colon carcinoma and head and neck squamous cell carcinoma (HNSCC). Isoform 1 is the major isoform in most peripheral tissues. Isoform 2 is abundant in most peripheral tissues. Isoform 3 is the major isoform in brain, female reproductive tissues, thyroid and heart. Within brain it is highly expressed in corpus callosum and pons. Isoform 6 is brain-specific, it is the major isoform in cerebellum and fetal brain. |
| Function | Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. |
| Protein Name | Microtubule-Associated Tumor Suppressor 1At2 Receptor-Binding ProteinAngiotensin-Ii Type 2 Receptor-Interacting ProteinMitochondrial Tumor Suppressor 1 |
| Database Links | |
| Cellular Localisation | MitochondrionGolgi ApparatusCell MembraneNucleusIn NeuronsTranslocates Into The Nucleus After Treatment With Angiotensin-IiIsoform 1: CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCytoplasmSpindleLocalizes With The Mitotic Spindle During Mitosis And With The Intercellular Bridge During Cytokinesis |
| Alternative Antibody Names | Anti-Microtubule-Associated Tumor Suppressor 1 antibodyAnti-At2 Receptor-Binding Protein antibodyAnti-Angiotensin-Ii Type 2 Receptor-Interacting Protein antibodyAnti-Mitochondrial Tumor Suppressor 1 antibodyAnti-MTUS1 antibodyAnti-ATBP antibodyAnti-ATIP antibodyAnti-GK1 antibodyAnti-KIAA1288 antibodyAnti-MTSG1 antibody |
Information sourced from Uniprot.org