| Tissue Specificity | Ubiquitously expressed (at protein level). Highly expressed in brain. Down-regulated in ovarian carcinoma, pancreas carcinoma, colon carcinoma and head and neck squamous cell carcinoma (HNSCC). Isoform 1 is the major isoform in most peripheral tissues. Isoform 2 is abundant in most peripheral tissues. Isoform 3 is the major isoform in brain, female reproductive tissues, thyroid and heart. Within brain it is highly expressed in corpus callosum and pons. Isoform 6 is brain-specific, it is the major isoform in cerebellum and fetal brain. |
| Function | Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. |
| Protein Name | Microtubule-Associated Tumor Suppressor 1At2 Receptor-Binding ProteinAngiotensin-Ii Type 2 Receptor-Interacting ProteinMitochondrial Tumor Suppressor 1 |
| Cellular Localisation | MitochondrionGolgi ApparatusCell MembraneNucleusIn NeuronsTranslocates Into The Nucleus After Treatment With Angiotensin-IiIsoform 1: CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCytoplasmSpindleLocalizes With The Mitotic Spindle During Mitosis And With The Intercellular Bridge During Cytokinesis |
| Alternative Antibody Names | Anti-Microtubule-Associated Tumor Suppressor 1 antibodyAnti-At2 Receptor-Binding Protein antibodyAnti-Angiotensin-Ii Type 2 Receptor-Interacting Protein antibodyAnti-Mitochondrial Tumor Suppressor 1 antibodyAnti-MTUS1 antibodyAnti-ATBP antibodyAnti-ATIP antibodyAnti-GK1 antibodyAnti-KIAA1288 antibodyAnti-MTSG1 antibody |
Information sourced from Uniprot.org
