Anti-MTRF1 antibody (STJA0009530)

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	MTRF1
Gene ID:	9617
Uniprot ID:	RF1M_HUMAN
Specificity:	This antibody detects endogenous levels of MTRF1 at Human, Mouse
Immunogen:	Synthesized peptide derived from human MTRF1

Function	Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain non-canonical stop codons AGG and AGA. Non-canonical termination codons AGG and AGA are found at the end of MT-CO1/COX1 and MT-ND6/ND6 open reading frames, respectively. Recognizes non-canonical stop codons via a network of interactions between the codon, MTRF1 and the ribosomal RNA (rRNA): in contrast to other translation release factors, which identify the codon in the A-site via direct interactions of amino acid side chains with the bases, MTRF1 repositions the first 2 bases of the stop codon to use an intricate network of interactions that includes residues of the release factor, the rRNA of the small ribosomal subunit, as well as neighboring bases of the mRNA.
Protein Name	Peptide Chain Release Factor 1 - Mitochondrial Mrf-1 Mtrf-1
Cellular Localisation	Mitochondrion
Alternative Antibody Names	Anti-Peptide Chain Release Factor 1 - Mitochondrial antibody Anti-Mrf-1 antibody Anti-Mtrf-1 antibody Anti-MTRF1 antibody

Information sourced from Uniprot.org

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