| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MTMR6 (382-621) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MTMR6 |
| Gene ID: |
9107 |
| Uniprot ID: |
MTMR6_HUMAN |
| Immunogen Region: |
382-621 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 382-621 of human MTMR6 (NP_004676.3). |
| Immunogen Sequence: |
RCGQLDGDPKEVSPVFTQFL ECVWHLTEQFPQAFEFSEAF LLQIHEHIHSCQFGNFLGNC QKEREELKLKEKTYSLWPFL LEDQKKYLNPLYSSESHRFT VLEPNTVSFNFKFWRNMYHQ FDRTLHPRQSVFNIIMNMNE QNKQLEKDIKDLESKIKQRK NKQTDGILTKELLHSVHPES PNLKTSLCFKEQTLLPVNDA LRTIEGSSPADNRYSEYAEE FSKSEPAVVSLEYGVARMT |
| Tissue Specificity | Expressed in CD4+ T-cells. |
| Function | Phosphatase that acts on lipids with a phosphoinositol headgroup. Dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,5-bisphosphate (Probable). Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) but also to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), phosphatidic acid and phosphatidylserine. Negatively regulates ER-Golgi protein transport. Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4(+) T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate. Negatively regulates proliferation of reactivated CD4(+) T-cells. In complex with MTMR9, negatively regulates DNA damage-induced apoptosis. The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels. |
| Protein Name | Myotubularin-Related Protein 6Phosphatidylinositol-3 -5-Bisphosphate 3-PhosphatasePhosphatidylinositol-3-Phosphate Phosphatase |
| Database Links | Reactome: R-HSA-1660499 |
| Cellular Localisation | CytoplasmEndoplasmic Reticulum-Golgi Intermediate CompartmentEndoplasmic ReticulumCell ProjectionRuffle MembranePeripheral Membrane ProteinCytoplasmic SidePerinuclear RegionLocalizes To Ruffles During Egf-Induced MacropinocytosisColocalizes With Mtmr9 To The Perinuclear RegionPartially Localizes To The Endoplasmic ReticulumCo-Localizes With Rab1b To The Endoplasmic Reticulum-Golgi Intermediate Compartment And To The Peri-Golgi Region |
| Alternative Antibody Names | Anti-Myotubularin-Related Protein 6 antibodyAnti-Phosphatidylinositol-3 -5-Bisphosphate 3-Phosphatase antibodyAnti-Phosphatidylinositol-3-Phosphate Phosphatase antibodyAnti-MTMR6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
