| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MTHFR (1-230) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MTHFR |
| Gene ID: |
4524 |
| Uniprot ID: |
MTHR_HUMAN |
| Immunogen Region: |
1-230 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human MTHFR (NP_005948.3). |
| Immunogen Sequence: |
MVNEARGNSSLNPCLEGSAS SGSESSKDSSRCSTPGLDPE RHERLREKMRRRLESGDKWF SLEFFPPRTAEGAVNLISRF DRMAAGGPLYIDVTWHPAGD PGSDKETSSMMIASTAVNYC GLETILHMTCCRQRLEEITG HLHKAKQLGLKNIMALRGDP IGDQWEEEEGGFNYAVDLVK HIRSEFGDYFDICVAGYPKG HPEAGSFEADLKHLKEKVSA GADFIITQLF |
| Post Translational Modifications | Phosphorylation of an N-terminal serine-rich phosphorylation region increases sensitivity to S-adenosylmethionine and inhibition. |
| Function | Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine. Represents a key regulatory connection between the folate and methionine cycles (Probable). |
| Protein Name | Methylenetetrahydrofolate ReductaseNadph |
| Database Links | Reactome: R-HSA-196757 |
| Alternative Antibody Names | Anti-Methylenetetrahydrofolate Reductase antibodyAnti-Nadph antibodyAnti-MTHFR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
