Anti-MTHFD1 antibody (Internal) (STJ71538)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-MTHFD1 (Internal) is suitable for use in ELISA, Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Applications | Pep-ELISA/WB/IHC/IF |
| Host | Goat |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Approx. 100kDa band observed in lysates of cell lines Jurkat and MOLT4 and approx.110kDa in lysates of cell line MCF7 (calculated MW of 102kDa according to NP_005947.2). Recommended co |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20ยฐC on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | MTHFD1 |
| Gene ID | 4522 |
| Uniprot ID | C1TC_HUMAN |
| Accession Number | NP_005947.2 |
| Immunogen Region | Internal |
| Immunogen Sequence | RGDLNDCFIPCTPK |
Additional Info
| Function | Trifunctional enzyme that catalyzes the interconversion of three forms of one-carbon-substituted tetrahydrofolate: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate, 5,10-methenyltetrahydrofolate and (6S)-10-formyltetrahydrofolate. These derivatives of tetrahydrofolate are differentially required in nucleotide and amino acid biosynthesis, (6S)-10-formyltetrahydrofolate being required for purine biosynthesis while (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate is used for serine and methionine biosynthesis for instance. |
| Protein Name | C-1-Tetrahydrofolate Synthase - CytoplasmicC1-Thf SynthaseEpididymis Secretory Sperm Binding Protein Cleaved Into - C-1-Tetrahydrofolate Synthase - Cytoplasmic - N-Terminally Processed Includes - Methylenetetrahydrofolate Dehydrogenase - Methenyltetrahydrofolate Cyclohydrolase - Formyltetrahydrofolate Synthetase |
| Database Links | Reactome: R-HSA-196757 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-C-1-Tetrahydrofolate Synthase - Cytoplasmic antibodyAnti-C1-Thf Synthase antibodyAnti-Epididymis Secretory Sperm Binding Protein Cleaved Into - C-1-Tetrahydrofolate Synthase - Cytoplasmic - N-Terminally Processed Includes - Methylenetetrahydrofolate Dehydrogenase - Methenyltetrahydrofolate Cyclohydrolase - Formyltetrahydrofolate Synthetase antibodyAnti-MTHFD1 antibodyAnti-MTHFC antibodyAnti-MTHFD antibody |
Information sourced from Uniprot.org