Anti-MTHFD1 antibody (1-270) (STJ111371)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MTHFD1 (1-270) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:200-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MTHFD1 |
| Gene ID | 4522 |
| Uniprot ID | C1TC_HUMAN |
| Immunogen Region | 1-270 |
| Immunogen Sequence | MAPAEILNGKEISAQIRARL KNQVTQLKEQVPGFTPRLAI LQVGNRDDSNLYINVKLKAA EEIGIKATHIKLPRTTTESE VMKYITSLNEDSTVHGFLVQ LPLDSENSINTEEVINAIAP EKDVDGLTSINAGKLARGDL NDCFIPCTPKGCLELIKETG VPIAGRHAVVVGRSKIVGAP MHDLLLWNNATVTTCHSKTA HLDEEVNKGDILVVATGQPE MVKGEWIKPGAIVIDCGIN |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human MTHFD1 (NP_005947.3). |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Function | Trifunctional enzyme that catalyzes the interconversion of three forms of one-carbon-substituted tetrahydrofolate: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate, 5,10-methenyltetrahydrofolate and (6S)-10-formyltetrahydrofolate. These derivatives of tetrahydrofolate are differentially required in nucleotide and amino acid biosynthesis, (6S)-10-formyltetrahydrofolate being required for purine biosynthesis while (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate is used for serine and methionine biosynthesis for instance. |
| Protein Name | C-1-Tetrahydrofolate Synthase - CytoplasmicC1-Thf SynthaseEpididymis Secretory Sperm Binding Protein Cleaved Into - C-1-Tetrahydrofolate Synthase - Cytoplasmic - N-Terminally Processed Includes - Methylenetetrahydrofolate Dehydrogenase - Methenyltetrahydrofolate Cyclohydrolase - Formyltetrahydrofolate Synthetase |
| Database Links | Reactome: R-HSA-196757 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-C-1-Tetrahydrofolate Synthase - Cytoplasmic antibodyAnti-C1-Thf Synthase antibodyAnti-Epididymis Secretory Sperm Binding Protein Cleaved Into - C-1-Tetrahydrofolate Synthase - Cytoplasmic - N-Terminally Processed Includes - Methylenetetrahydrofolate Dehydrogenase - Methenyltetrahydrofolate Cyclohydrolase - Formyltetrahydrofolate Synthetase antibodyAnti-MTHFD1 antibodyAnti-MTHFC antibodyAnti-MTHFD antibody |
Information sourced from Uniprot.org