Anti-MTERF1 antibody (267-316) (STJ94273)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from human MTERF. AA range:267-316
General Information
| Short Description | Rabbit polyclonal anti-Transcription termination factor 1, mitochondrial (267-316) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MTERF1 |
| Gene ID | 7978 |
| Uniprot ID | MTEF1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MTERF. AA range:267-316 |
| Immunogen Region | 267-316 |
| Specificity | mTERF Polyclonal Antibody detects endogenous levels of mTERF protein. |
Additional Info
| Post Translational Modifications | Phosphoprotein with mostly four phosphate groups. While the DNA-binding activity is unaffected by the phosphorylation state, only the phosphorylated form of the protein is active for termination activity. Functioning seems to be regulated by phosphorylation. |
| Function | Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene.this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Transcription termination activity appears to be polarized with highest specificity for transcripts initiated on the light strand. |
| Protein Name | Transcription Termination Factor 1 - MitochondrialMitochondrial Transcription Termination Factor 1MterfMterf1 |
| Database Links | Reactome: R-HSA-163316Reactome: R-HSA-2151201 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Transcription Termination Factor 1 - Mitochondrial antibodyAnti-Mitochondrial Transcription Termination Factor 1 antibodyAnti-Mterf antibodyAnti-Mterf1 antibodyAnti-MTERF1 antibodyAnti-MTERF antibody |
Information sourced from Uniprot.org