Anti-MTDH antibody [2F11C3] (STJ98256)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenPurified recombinant fragment of human MTDH expressed in E. Coli.
General Information
| Short Description | Mouse monoclonal anti-Protein LYRIC for use in WB, IHC, IF, FC and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/FC/ELISA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 2F11C3 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | WB 1:500-1:2000IHC 1:200-1:1000FC 1:200-1:400ELISA 1:10000IF 1:50-200 |
| Formulation | Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MTDH |
| Gene ID | 92140 |
| Uniprot ID | LYRIC_HUMAN |
| Immunogen | Purified recombinant fragment of human MTDH expressed in E. Coli. |
| Specificity | MTDH Monoclonal Antibody detects endogenous levels of MTDH protein. |
Additional Info
| Function | Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. |
| Protein Name | Protein Lyric3d3/LyricAstrocyte Elevated Gene-1 ProteinAeg-1Lysine-Rich Ceacam1 Co-Isolated ProteinMetadherinMetastasis Adhesion Protein |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinNucleus MembraneCell JunctionTight JunctionNucleusNucleolusCytoplasmPerinuclear RegionIn Epithelial CellsRecruited To Tight Junctions (Tj) During The Maturation Of The Tj ComplexesA Nucleolar Staining May Be Due To Nuclear Targeting Of An Isoform Lacking The Transmembrane DomainTnf-Alpha Causes Translocation From The Cytoplasm To The Nucleus |
| Alternative Antibody Names | Anti-Protein Lyric antibodyAnti-3d3/Lyric antibodyAnti-Astrocyte Elevated Gene-1 Protein antibodyAnti-Aeg-1 antibodyAnti-Lysine-Rich Ceacam1 Co-Isolated Protein antibodyAnti-Metadherin antibodyAnti-Metastasis Adhesion Protein antibodyAnti-MTDH antibodyAnti-AEG1 antibodyAnti-LYRIC antibody |
Information sourced from Uniprot.org