Anti-MTBP antibody (1-300) (STJ114241)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MTBP (1-300) antibody for use in WB and ELISA in mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MTBP |
| Gene ID | 27085 |
| Uniprot ID | MTBP_HUMAN |
| Immunogen Region | 1-300 |
| Immunogen Sequence | MDRYLLLVIWGEGKFPSAAS REAEHGPEVSSGEGTENQPD FTAANVYHLLKRSISASINP EDSTFPACSVGGIPGSKKWF FAVQAIYGFYQFCSSDWQEI HFDTEKDKIEDVLQTNIEEC LGAVECFEEEDSNSRESLSL ADLYEEAAENLHQLSDKLPA PGRAMVDIILLLSDKDPPKL KDYLPTVGALKHLREWYSAK ITIAGNHCEINCQKIAEYLS ANVVSLEDLRNVIDSKELW |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human MTBP (NP_071328.2). |
Additional Info
| Function | Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells. May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation. |
| Protein Name | Mdm2-Binding ProteinHmtbp |
| Database Links | |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Mdm2-Binding Protein antibodyAnti-Hmtbp antibodyAnti-MTBP antibody |
Information sourced from Uniprot.org