Anti-MST3 antibody (460-517) {Biotin} (STJ506033)

SKU:
STJ506033-100

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Host: Rabbit
Applications: ELISA/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-MST3 (460-517) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Biotin
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5-1.5 µg/µl
Dilution Range: WB: 1:500
ELISA: 1:50, 000
IP: 1:200
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: STK24
Gene ID: 8428
Uniprot ID: STK24_HUMAN
Immunogen Region: 460-517
Immunogen: Synthetic peptide taken within amino acid region 460-517 on human Mammalian STE20-like protein kinase 3/STE20-like kinase MST3/STK24.
Tissue Specificity Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex.
Post Translational Modifications Proteolytically processed by caspases during apoptosis. Proteolytic cleavage results in kinase activation, nuclear translocation of the truncated form (MST3/N) and the induction of apoptosis. Isoform B is activated by phosphorylation by PKA. Oxidative stress induces phosphorylation. Activated by autophosphorylation at Thr-190 and phosphorylation at this site is essential for its function. Manganese, magnesium and cobalt-dependent autophosphorylation is mainly on threonine residues while zinc-dependent autophosphorylation is on both serine and threonine residues.
Function Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation. Regulates also cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.
Protein Name Serine/Threonine-Protein Kinase 24
Mammalian Ste20-Like Protein Kinase 3
Mst-3
Ste20-Like Kinase Mst3 Cleaved Into - Serine/Threonine-Protein Kinase 24 36 Kda Subunit
Mammalian Ste20-Like Protein Kinase 3 N-Terminal
Mst3/N - Serine/Threonine-Protein Kinase 24 12 Kda Subunit
Mammalian Ste20-Like Protein Kinase 3 C-Terminal
Mst3/C
Database Links Reactome: R-HSA-111465
Reactome: R-HSA-75153
Cellular Localisation Cytoplasm
Nucleus
Membrane
The Truncated Form (Mst3/N) Translocates To The Nucleus
Colocalizes With Stk38l In The Membrane
Alternative Antibody Names Anti-Serine/Threonine-Protein Kinase 24 antibody
Anti-Mammalian Ste20-Like Protein Kinase 3 antibody
Anti-Mst-3 antibody
Anti-Ste20-Like Kinase Mst3 Cleaved Into - Serine/Threonine-Protein Kinase 24 36 Kda Subunit antibody
Anti-Mammalian Ste20-Like Protein Kinase 3 N-Terminal antibody
Anti-Mst3/N - Serine/Threonine-Protein Kinase 24 12 Kda Subunit antibody
Anti-Mammalian Ste20-Like Protein Kinase 3 C-Terminal antibody
Anti-Mst3/C antibody
Anti-STK24 antibody
Anti-MST3 antibody
Anti-STK3 antibody

Information sourced from Uniprot.org

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