Anti-MSL3 antibody (STJA0009348)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human MSL3
General Information
| Short Description | Rabbit polyclonal anti-Male-specific lethal 3 homolog for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MSL3 |
| Gene ID | 10943 |
| Uniprot ID | MS3L1_HUMAN |
| Immunogen | Synthesized peptide derived from human MSL3 |
| Specificity | This antibody detects endogenous levels of MSL3 at Human, Mouse |
Additional Info
| Function | Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction. The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac. The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome. X up-regulation is required to compensate for autosomal biallelic expression. The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA. Acts as a histone reader that specifically recognizes and binds histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex. May play a role X inactivation in females. |
| Protein Name | Msl Complex Subunit 3Male-Specific Lethal 3 HomologMale-Specific Lethal-3 Homolog 1Male-Specific Lethal-3 Protein-Like 1Msl3-Like 1 |
| Database Links | Reactome: R-HSA-3214847 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Msl Complex Subunit 3 antibodyAnti-Male-Specific Lethal 3 Homolog antibodyAnti-Male-Specific Lethal-3 Homolog 1 antibodyAnti-Male-Specific Lethal-3 Protein-Like 1 antibodyAnti-Msl3-Like 1 antibodyAnti-MSL3 antibodyAnti-MSL3L1 antibody |
Information sourced from Uniprot.org