Anti-MSL1 antibody (210-300) (STJ119888)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MSL1 (210-300) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MSL1 |
| Gene ID | 339287 |
| Uniprot ID | MSL1_HUMAN |
| Immunogen Region | 210-300 |
| Immunogen Sequence | LAVPSWRDHSVEPLRDPNPS DLLENLDDSVFSKRHAKLEL DEKRRKRWDIQRIREQRILQ RLQLRMYKKKGIQESEPEVT SFFPEPDDVES |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 210-300 of human MSL1 (NP_001012241). |
Additional Info
| Post Translational Modifications | Sumoylated with SUMO1. |
| Function | Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction. The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac. The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome. X up-regulation is required to compensate for autosomal biallelic expression. The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA. Within the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. |
| Protein Name | Male-Specific Lethal 1 HomologMsl-1Male-Specific Lethal 1-Like 1Msl1-Like 1Male-Specific Lethal-1 Homolog 1 |
| Database Links | Reactome: R-HSA-3214847 |
| Cellular Localisation | NucleusNucleoplasmNucleus Speckle |
| Alternative Antibody Names | Anti-Male-Specific Lethal 1 Homolog antibodyAnti-Msl-1 antibodyAnti-Male-Specific Lethal 1-Like 1 antibodyAnti-Msl1-Like 1 antibodyAnti-Male-Specific Lethal-1 Homolog 1 antibodyAnti-MSL1 antibodyAnti-MSL1L1 antibody |
Information sourced from Uniprot.org