Anti-mSin3A antibody [R08-4C2] (STJA0036516)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human mSin3A
General Information
| Short Description | Rabbit monoclonal anti-mSin3A for use in WB, IHC-P, ICC, IF and FC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ICC/IF/FC |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R08-4C2 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200FC 1:50-1:100 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | SIN3A |
| Gene ID | 25942 |
| Uniprot ID | SIN3A_HUMAN |
| Immunogen | A synthesized peptide derived from human mSin3A |
Additional Info
| Tissue Specificity | Expressed in the developing brain, with highest levels of expression detected in the ventricular zone of various cortical regions. |
| Post Translational Modifications | SUMO1 sumoylated by TOPORS. Probably desumoylated by SENP2. |
| Function | Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression. Required for cortical neuron differentiation and callosal axon elongation. |
| Protein Name | Paired Amphipathic Helix Protein Sin3aHistone Deacetylase Complex Subunit Sin3aTranscriptional Corepressor Sin3a |
| Database Links | Reactome: R-HSA-3899300Reactome: R-HSA-400206Reactome: R-HSA-427413Reactome: R-HSA-8936459Reactome: R-HSA-9022538Reactome: R-HSA-9022692Reactome: R-HSA-9022699Reactome: R-HSA-9022702Reactome: R-HSA-9615017Reactome: R-HSA-9701898Reactome: R-HSA-9707564Reactome: R-HSA-9824594Reactome: R-HSA-9825892Reactome: R-HSA-983231 |
| Cellular Localisation | NucleusNucleolusRecruited To The Nucleolus By Sap30l |
| Alternative Antibody Names | Anti-Paired Amphipathic Helix Protein Sin3a antibodyAnti-Histone Deacetylase Complex Subunit Sin3a antibodyAnti-Transcriptional Corepressor Sin3a antibodyAnti-SIN3A antibody |
Information sourced from Uniprot.org