Anti-MRP5 antibody [M5I-1] (STJ16100899)

SKU:
STJ16100899-1

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Host: Rat
Applications: ICC/IHC-F/FC/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rat monoclonal antibody anti-MRP5 is suitable for use in Immunocytochemistry, Immunohistochemistry, Flow Cytometry and Western Blot research applications.
Clonality: Monoclonal
Clone ID: M5I-1
Conjugation: Unconjugated
Isotype: IgG2a
Formulation: supernatant with 0.7% BSA and 0.1% sodium azide
Concentration: 250 ug/mL
Dilution Range: ICC 1:20-1:50
IHC-F 1:20
FC
WB 1:50
Storage Instruction: Store at 2-8°C upon receipt.
Gene Symbol: ABCC5
Gene ID: 10057
Uniprot ID: MRP5_HUMAN
Immunogen: MRP5 aa 82-168
Tissue Specificity Isoform 3: Predominant isoform in retinal pigment epithelium, bladder, and stomach. Ubiquitously expressed, but levels in brain and muscle are especially high. All isoforms are equally expressed in retina.
Function ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of endogenous metabolites such as cAMP and cGMP, folic acid and N-lactoyl-amino acids (in vitro). Acts also as a general glutamate conjugate and analog transporter that can limit the brain levels of endogenous metabolites, drugs, and toxins. Confers resistance to the antiviral agent PMEA. Able to transport several anticancer drugs including methotrexate, and nucleotide analogs in vitro, however it does with low affinity, thus the exact role of ABCC5 in mediating resistance still needs to be elucidated. Acts as a heme transporter required for the translocation of cytosolic heme to the secretory pathway. May play a role in energy metabolism by regulating the glucagon-like peptide 1 (GLP-1) secretion from enteroendocrine cells.
Protein Name Atp-Binding Cassette Sub-Family C Member 5
Multi-Specific Organic Anion Transporter C
Moat-C
Multidrug Resistance-Associated Protein 5
Smrp
Pabc11
Database Links Reactome: R-HSA-2142850
Reactome: R-HSA-382556
Reactome: R-HSA-9748787
Reactome: R-HSA-9753281
Cellular Localisation Basolateral Cell Membrane
Multi-Pass Membrane Protein
Golgi Apparatus Lumen
Endosome Membrane
Cytoplasmic Granule
Apical Cell Membrane
In Most Cells
Routes To The Basolateral Plasma Membrane
But In The Brain Capillary Endothelial Cells That Form The Blood-Brain Barrier
Resides In The Apical Membrane
Alternative Antibody Names Anti-Atp-Binding Cassette Sub-Family C Member 5 antibody
Anti-Multi-Specific Organic Anion Transporter C antibody
Anti-Moat-C antibody
Anti-Multidrug Resistance-Associated Protein 5 antibody
Anti-Smrp antibody
Anti-Pabc11 antibody
Anti-ABCC5 antibody
Anti-MRP5 antibody

Information sourced from Uniprot.org

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