Anti-MRP1 antibody [MRPr1] (STJ16100888)
SPECIFICATIONS
ClonalityMonoclonal
HostRat
ConjugationUnconjugated
IsotypeIgG2a
Immunogen168 aa amino-proximal half of protein
General Information
| Short Description | Rat monoclonal anti-MRP1 for use in FC, WB, ICC, IHC-F and IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC/WB/ICC/IHC-F/IHC-P |
| Host | Rat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | MRPr1 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Concentration | 250 Mu g/mL |
| Dilution Range | FCWBICCIHC-FIHC-P 1:20-1:50 |
| Formulation | Serum free tissue culture supernatant with 07% BSA and 0.1% sodium azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Gene Symbol | MSH3 |
| Gene ID | 4437 |
| Uniprot ID | MSH3_HUMAN |
| Immunogen | 168 aa amino-proximal half of protein |
Additional Info
| Function | Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. |
| Protein Name | Dna Mismatch Repair Protein Msh3Hmsh3Divergent Upstream ProteinDupMismatch Repair Protein 1Mrp1 |
| Database Links | Reactome: R-HSA-5358606Reactome: R-HSA-5632927Reactome: R-HSA-5632928 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Dna Mismatch Repair Protein Msh3 antibodyAnti-Hmsh3 antibodyAnti-Divergent Upstream Protein antibodyAnti-Dup antibodyAnti-Mismatch Repair Protein 1 antibodyAnti-Mrp1 antibodyAnti-MSH3 antibodyAnti-DUC1 antibodyAnti-DUG antibody |
Information sourced from Uniprot.org