Anti-MRM3 antibody (1-420) (STJ116260)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MRM3 (1-420) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MRM3 |
| Gene ID | 55178 |
| Uniprot ID | MRM3_HUMAN |
| Immunogen Region | 1-420 |
| Immunogen Sequence | MAALVRPARFVVRPLLQVVQ AWDLDARRWVRALRRSPVKV VFPSGEVVEQKRAPGKQPRK APSEASAQEQREKQPLEESA SRAPSTWEESGLRYDKAYPG DRRLSSVMTIVKSRPFREKQ GKILLEGRRLISDALKAGAV PKMFFFSRLEYLKELPVDKL KGVSLIKVKFEDIKDWSDLV TPQGIMGIFAKPDHVKMTYP KTQLQHSLPLLLICDNLRDP GNLGTILRSAAGAGCSKVL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-420 of human MRM3 (NP_060616.1). |
Additional Info
| Tissue Specificity | Expressed at same level in normal liver and hepatocarcinoma. |
| Function | S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1370 (Gm1370) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA. Also required for formation of 2'-O-methyluridine at position 1369 (Um1369) mediated by MRM2. |
| Protein Name | Rrna Methyltransferase 3 - Mitochondrial16s RrnaGuanosine(1370-2'-O-Methyltransferase16s Rrna Gm1370 2'-O-MethyltransferaseRna Methyltransferase-Like Protein 1 |
| Database Links | Reactome: R-HSA-6793080 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Rrna Methyltransferase 3 - Mitochondrial antibodyAnti-16s Rrna antibodyAnti-Guanosine(1370-2'-O-Methyltransferase antibodyAnti-16s Rrna Gm1370 2'-O-Methyltransferase antibodyAnti-Rna Methyltransferase-Like Protein 1 antibodyAnti-MRM3 antibodyAnti-RNMTL1 antibodyAnti-HC90 antibody |
Information sourced from Uniprot.org