Anti-MRGPRX1 antibody (263-322) (STJ115108)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MRGPRX1 (263-322) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MRGPRX1 |
| Gene ID | 259249 |
| Uniprot ID | MRGX1_HUMAN |
| Immunogen Region | 263-322 |
| Immunogen Sequence | LNSSANPIIYFFVGSFRQRQ NRQNLKLVLQRALQDASEVD EGGGQLPEEILELSGSRLEQ |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 263-322 of human MRGPRX1 (NP_671732.3). |
Additional Info
| Tissue Specificity | Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons. |
| Function | Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine-induced itch, in a histamine-independent manner. |
| Protein Name | Mas-Related G-Protein Coupled Receptor Member X1Sensory Neuron-Specific G-Protein Coupled Receptor 3/4 |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Mas-Related G-Protein Coupled Receptor Member X1 antibodyAnti-Sensory Neuron-Specific G-Protein Coupled Receptor 3/4 antibodyAnti-MRGPRX1 antibodyAnti-MRGX1 antibodyAnti-SNSR3 antibodyAnti-SNSR4 antibody |
Information sourced from Uniprot.org