Anti-MRC2 antibody [R04-8M1] (STJA0037113)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human MRC2
General Information
| Short Description | Rabbit monoclonal anti-MRC2 for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R04-8M1 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | MRC2 |
| Gene ID | 9902 |
| Uniprot ID | MRC2_HUMAN |
| Immunogen | A synthesized peptide derived from human MRC2 |
Additional Info
| Tissue Specificity | Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney. |
| Post Translational Modifications | N-glycosylated. |
| Function | May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs). |
| Protein Name | C-Type Mannose Receptor 2C-Type Lectin Domain Family 13 Member EEndocytic Receptor 180Macrophage Mannose Receptor 2Urokinase-Type Plasminogen Activator Receptor-Associated ProteinUpar-Associated ProteinUrokinase Receptor-Associated ProteinCd Antigen Cd280 |
| Database Links | Reactome: R-HSA-1236978 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-C-Type Mannose Receptor 2 antibodyAnti-C-Type Lectin Domain Family 13 Member E antibodyAnti-Endocytic Receptor 180 antibodyAnti-Macrophage Mannose Receptor 2 antibodyAnti-Urokinase-Type Plasminogen Activator Receptor-Associated Protein antibodyAnti-Upar-Associated Protein antibodyAnti-Urokinase Receptor-Associated Protein antibodyAnti-Cd Antigen Cd280 antibodyAnti-MRC2 antibodyAnti-CLEC13E antibodyAnti-ENDO180 antibodyAnti-KIAA0709 antibodyAnti-UPARAP antibody |
Information sourced from Uniprot.org