| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Melanocortin-2 receptor accessory protein (20-100 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MRAP |
| Gene ID: | 56246 |
| Uniprot ID: | MRAP_HUMAN |
| Immunogen Region: | 20-100 aa |
| Specificity: | MRAP Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 20-100 |
| Function | Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells. |
| Protein Name | Melanocortin-2 Receptor Accessory Protein B27 Fat Cell-Specific Low Molecular Weight Protein Fat Tissue-Specific Low Mw Protein |
| Cellular Localisation | Cell Membrane Single-Pass Membrane Protein Endoplasmic Reticulum Membrane The Formation Of Antiparallel Homo- And Heterodimers Suggest That N- And C-Terminus Can Both Localize In The Cytoplasmic And Extracellular Parts Depending On The Context Upon Insulin Stimulation It Is Redistributed Into Spotty Structures Throughout The Cytoplasm |
| Alternative Antibody Names | Anti-Melanocortin-2 Receptor Accessory Protein antibody Anti-B27 antibody Anti-Fat Cell-Specific Low Molecular Weight Protein antibody Anti-Fat Tissue-Specific Low Mw Protein antibody Anti-MRAP antibody Anti-C21orf61 antibody Anti-FALP antibody |
Information sourced from Uniprot.org