Anti-MP1/LAMTOR3 antibody (1-124aa) [AT1F10] (STJA0041876)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2bk
ImmunogenRecombinant human MAPKSP1 (1-124aa) purified from E. coli
General Information
| Short Description | Mouse monoclonal anti-MP1/LAMTOR3 (1-124aa) for use in ELISA, WB, ICC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB/ICC/IF |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | AT1F10 |
| Isotype | IgG2bk |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | By protein-A affinity chromatography |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LAMTOR3 |
| Gene ID | 8649 |
| Uniprot ID | LTOR3_HUMAN |
| Accession Number | NP_068805 |
| Immunogen | Recombinant human MAPKSP1 (1-124aa) purified from E. coli |
| Immunogen Region | 1-124aa |
Additional Info
| Function | As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2. |
| Protein Name | Ragulator Complex Protein Lamtor3Late Endosomal/Lysosomal Adaptor And Mapk And Mtor Activator 3Mek-Binding Partner 1Mp1Mitogen-Activated Protein Kinase Kinase 1-Interacting Protein 1Mitogen-Activated Protein Kinase Scaffold Protein 1 |
| Database Links | Reactome: R-HSA-1632852Reactome: R-HSA-165159Reactome: R-HSA-166208Reactome: R-HSA-380972Reactome: R-HSA-5628897Reactome: R-HSA-5674135Reactome: R-HSA-6798695Reactome: R-HSA-8943724Reactome: R-HSA-9639288 |
| Cellular Localisation | Late Endosome MembranePeripheral Membrane ProteinCytoplasmic SideRecruited To Lysosome And Endosome Membranes By Lamtor1 |
| Alternative Antibody Names | Anti-Ragulator Complex Protein Lamtor3 antibodyAnti-Late Endosomal/Lysosomal Adaptor And Mapk And Mtor Activator 3 antibodyAnti-Mek-Binding Partner 1 antibodyAnti-Mp1 antibodyAnti-Mitogen-Activated Protein Kinase Kinase 1-Interacting Protein 1 antibodyAnti-Mitogen-Activated Protein Kinase Scaffold Protein 1 antibodyAnti-LAMTOR3 antibodyAnti-MAP2K1IP1 antibodyAnti-MAPKSP1 antibodyAnti-PRO2783 antibody |
Information sourced from Uniprot.org