Anti-MORC3 antibody (STJA0008323)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human MORC3
General Information
| Short Description | Rabbit polyclonal anti-MORC family CW-type zinc finger protein 3 for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MORC3 |
| Gene ID | 23515 |
| Uniprot ID | MORC3_HUMAN |
| Immunogen | Synthesized peptide derived from human MORC3 |
| Specificity | This antibody detects endogenous levels of MORC3 at Human |
Additional Info
| Post Translational Modifications | Sumoylation is involved in interaction with PML and localization to PML nuclear bodies. |
| Function | Nuclear matrix protein which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism and plays a role in innate immunity by restricting different viruses through modulation of the IFN response. Mechanistically, possesses a primary antiviral function through a MORC3-regulated element that activates IFNB1, and this function is guarded by a secondary IFN-repressing function. Sumoylated MORC3-NBs associates with PML-NBs and recruits TP53 and SP100, thus regulating TP53 activity. Binds RNA in vitro. Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3. The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0. (Microbial infection) May be required for influenza A transcription during viral infection. |
| Protein Name | Morc Family Cw-Type Zinc Finger Protein 3Nuclear Matrix Protein 2Zinc Finger Cw-Type Coiled-Coil Domain Protein 3 |
| Database Links | |
| Cellular Localisation | NucleusNucleoplasmNucleus MatrixPml BodyChromosomeAlso Found In Pml-Independent Nuclear BodiesLocalization To Nuclear Bodies Is Atp-Dependent |
| Alternative Antibody Names | Anti-Morc Family Cw-Type Zinc Finger Protein 3 antibodyAnti-Nuclear Matrix Protein 2 antibodyAnti-Zinc Finger Cw-Type Coiled-Coil Domain Protein 3 antibodyAnti-MORC3 antibodyAnti-KIAA0136 antibodyAnti-NXP2 antibodyAnti-ZCWCC3 antibody |
Information sourced from Uniprot.org