• Western blot analysis of lysates from 293, COS7, and HUVEC cells, treated with IFN 2500U/ml 30', using MOL1A Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of various cells using Mob1A Polyclonal Antibody

Anti-MOB1B antibody (101-150) (STJ94175)

SKU:
STJ94175

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Monkey
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-MOB kinase activator 1B (101-150) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: MOB1B
Gene ID: 92597
Uniprot ID: MOB1B_HUMAN
Immunogen Region: 101-150
Specificity: Mob1A Polyclonal Antibody detects endogenous levels of Mob1A protein.
Immunogen: The antiserum was produced against synthesized peptide derived from human MOL1A. AA range:101-150
Tissue Specificity Adrenal gland, bone marrow, brain, lung, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, uterus, colon with mucosa, fetal brain and fetal liver.
Post Translational Modifications Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1.
Function Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.
Protein Name Mob Kinase Activator 1b
Mob1 Homolog 1a
Mob1a
Mob1b
Mps One Binder Kinase Activator-Like 1a
Database Links Reactome: R-HSA-2028269
Cellular Localisation Cytoplasm
Nucleus
Alternative Antibody Names Anti-Mob Kinase Activator 1b antibody
Anti-Mob1 Homolog 1a antibody
Anti-Mob1a antibody
Anti-Mob1b antibody
Anti-Mps One Binder Kinase Activator-Like 1a antibody
Anti-MOB1B antibody
Anti-MOB4A antibody
Anti-MOBKL1A antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance