Anti-MOB1B antibody (101-150) (STJ94175)

Name: Anti-MOB1B antibody (101-150) (STJ94175)
SKU: STJ94175
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

ImmunogenThe antiserum was produced against synthesized peptide derived from human MOL1A. AA range:101-150

STJ94175

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Short Description	Rabbit polyclonal anti-MOB kinase activator 1B (101-150) for use in WB, IHC, IF and ELISA in Human, Mouse and Monkey samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IHC/IF/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Monkey
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	1 mg/mL
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Dilution Range	WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:40000 IF 1:50-200
Formulation	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	MOB1B
Gene ID	92597
Uniprot ID	MOB1B_HUMAN
Immunogen	The antiserum was produced against synthesized peptide derived from human MOL1A. AA range:101-150
Immunogen Region	101-150
Specificity	Mob1A Polyclonal Antibody detects endogenous levels of Mob1A protein.

Tissue Specificity	Adrenal gland, bone marrow, brain, lung, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, uterus, colon with mucosa, fetal brain and fetal liver.
Post Translational Modifications	Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1.
Function	Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.
Protein Name	Mob Kinase Activator 1b Mob1 Homolog 1a Mob1a Mob1b Mps One Binder Kinase Activator-Like 1a
Database Links	Reactome: R-HSA-2028269
Cellular Localisation	Cytoplasm Nucleus
Alternative Antibody Names	Anti-Mob Kinase Activator 1b antibody Anti-Mob1 Homolog 1a antibody Anti-Mob1a antibody Anti-Mob1b antibody Anti-Mps One Binder Kinase Activator-Like 1a antibody Anti-MOB1B antibody Anti-MOB4A antibody Anti-MOBKL1A antibody

Information sourced from Uniprot.org