| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Modulator of apoptosis 1 is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MOAP1 |
| Gene ID: |
64112 |
| Uniprot ID: |
MOAP1_HUMAN |
| Specificity: |
MOAP1 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from part of the human protein |
| Post Translational Modifications | Ubiquitinated and degraded during mitotic exit by APC/C-Cdh1, this modification is inhibited by TRIM39. |
| Function | Retrotransposon-derived protein that forms virion-like capsids. Acts as an effector of BAX during apoptosis: enriched at outer mitochondria membrane and associates with BAX upon induction of apoptosis, facilitating BAX-dependent mitochondrial outer membrane permeabilization and apoptosis. Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Also promotes autophagy: promotes phagophore closure via association with ATG8 proteins. Acts as an inhibitor of the NFE2L2/NRF2 pathway via interaction with SQSTM1: interaction promotes dissociation of SQSTM1 inclusion bodies that sequester KEAP1, relieving inactivation of the BCR(KEAP1) complex. |
| Protein Name | Modulator Of Apoptosis 1Map-1Map1Paraneoplastic Antigen Ma4 |
| Cellular Localisation | CytoplasmCytosolMitochondrion Outer MembraneExtracellular Vesicle MembraneForms Virion-Like Extracellular Vesicles That Are Released From Cells |
| Alternative Antibody Names | Anti-Modulator Of Apoptosis 1 antibodyAnti-Map-1 antibodyAnti-Map1 antibodyAnti-Paraneoplastic Antigen Ma4 antibodyAnti-MOAP1 antibodyAnti-PNMA4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
