Anti-MMP20 antibody (108-310) (STJ111833)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MMP20 (108-310) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MMP20 |
| Gene ID | 9313 |
| Uniprot ID | MMP20_HUMAN |
| Immunogen Region | 108-310 |
| Immunogen Sequence | YRLFPGEPKWKKNTLTYRIS KYTPSMSSVEVDKAVEMALQ AWSSAVPLSFVRINSGEADI MISFENGDHGDSYPFDGPRG TLAHAFAPGEGLGGDTHFDN AEKWTMGTNGFNLFTVAAHE FGHALGLAHSTDPSALMYPT YKYKNPYGFHLPKDDVKGIQ ALYGPRKVFLGKPTLPHAPH HKPSIPDLCDSSSSFDAVTM LGK |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 108-310 of human MMP20 (NP_004762.2). |
Additional Info
| Tissue Specificity | Expressed specifically in the enamel organ. |
| Post Translational Modifications | Autoactivates at least at the 107-Asn-|-Tyr-108 site. |
| Function | Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Cleaves aggrecan at the '360-Asn-|-Phe-361' site. |
| Protein Name | Matrix Metalloproteinase-20Mmp-20Enamel MetalloproteinaseEnamelysin |
| Database Links | Reactome: R-HSA-1442490Reactome: R-HSA-1474228Reactome: R-HSA-2022090 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Matrix Metalloproteinase-20 antibodyAnti-Mmp-20 antibodyAnti-Enamel Metalloproteinase antibodyAnti-Enamelysin antibodyAnti-MMP20 antibody |
Information sourced from Uniprot.org