| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MMP20 |
| Gene ID: | 9313 |
| Uniprot ID: | MMP20_HUMAN |
| Immunogen Region: | 108-310 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 108-310 of human MMP20 (NP_004762.2). |
| Immunogen Sequence: | YRLFPGEPKWKKNTLTYRIS KYTPSMSSVEVDKAVEMALQ AWSSAVPLSFVRINSGEADI MISFENGDHGDSYPFDGPRG TLAHAFAPGEGLGGDTHFDN AEKWTMGTNGFNLFTVAAHE FGHALGLAHSTDPSALMYPT YKYKNPYGFHLPKDDVKGIQ ALYGPRKVFLGKPTLPHAPH HKPSIPDLCDSSSSFDAVTM LGK |
| Tissue Specificity | Expressed specifically in the enamel organ. |
| Post Translational Modifications | Autoactivates at least at the 107-Asn-|-Tyr-108 site. |
| Function | Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Cleaves aggrecan at the '360-Asn-|-Phe-361' site. |
| Protein Name | Matrix Metalloproteinase-20 Mmp-20 Enamel Metalloproteinase Enamelysin |
| Database Links | Reactome: R-HSA-1442490 Reactome: R-HSA-1474228 Reactome: R-HSA-2022090 |
| Cellular Localisation | Secreted Extracellular Space Extracellular Matrix |
| Alternative Antibody Names | Anti-Matrix Metalloproteinase-20 antibody Anti-Mmp-20 antibody Anti-Enamel Metalloproteinase antibody Anti-Enamelysin antibody Anti-MMP20 antibody |
Information sourced from Uniprot.org