Anti-MMP17 antibody [R01-3X6] (STJA0036793)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human MMP17
General Information
| Short Description | Rabbit monoclonal anti-MMP17 for use in WB, IHC-P, ICC and IF in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ICC/IF |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R01-3X6 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | MMP17 |
| Gene ID | 4326 |
| Uniprot ID | MMP17_HUMAN |
| Immunogen | A synthesized peptide derived from human MMP17 |
Additional Info
| Tissue Specificity | Expressed in brain, leukocytes, colon, ovary testis and breast cancer. Expressed also in many transformed and non-transformed cell types. |
| Post Translational Modifications | The precursor is cleaved by a furin endopeptidase. |
| Function | Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Cleaves pro-TNF-alpha at the '74-Ala-|-Gln-75' site. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin. |
| Protein Name | Matrix Metalloproteinase-17Mmp-17Membrane-Type Matrix Metalloproteinase 4Mt-Mmp 4Mtmmp4Membrane-Type-4 Matrix MetalloproteinaseMt4-MmpMt4mmp |
| Database Links | Reactome: R-HSA-1592389 |
| Cellular Localisation | Isoform Long: Cell MembraneLipid-AnchorGpi-AnchorExtracellular SideSecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Matrix Metalloproteinase-17 antibodyAnti-Mmp-17 antibodyAnti-Membrane-Type Matrix Metalloproteinase 4 antibodyAnti-Mt-Mmp 4 antibodyAnti-Mtmmp4 antibodyAnti-Membrane-Type-4 Matrix Metalloproteinase antibodyAnti-Mt4-Mmp antibodyAnti-Mt4mmp antibodyAnti-MMP17 antibodyAnti-MT4MMP antibody |
Information sourced from Uniprot.org