Anti-MMP17 antibody (265-565) (STJ24580)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MMP17 (265-565) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MMP17 |
| Gene ID | 4326 |
| Uniprot ID | MMP17_HUMAN |
| Immunogen Region | 265-565 |
| Immunogen Sequence | IMRPYYQGPVGDPLRYGLPY EDKVRVWQLYGVRESVSPTA QPEEPPLLPEPPDNRSSAPP RKDVPHRCSTHFDAVAQIRG EAFFFKGKYFWRLTRDRHLV SLQPAQMHRFWRGLPLHLDS VDAVYERTSDHKIVFFKGDR YWVFKDNNVEEGYPRPVSDF SLPPGGIDAAFSWAHNDRTY FFKDQLYWRYDDHTRHMDPG YPAQSPLWRGVPSTLDDAMR WSDGASYFFRGQEYWKVLD |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 265-565 of human MMP17 (NP_057239.4). |
Additional Info
| Tissue Specificity | Expressed in brain, leukocytes, colon, ovary testis and breast cancer. Expressed also in many transformed and non-transformed cell types. |
| Post Translational Modifications | The precursor is cleaved by a furin endopeptidase. |
| Function | Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Cleaves pro-TNF-alpha at the '74-Ala-|-Gln-75' site. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin. |
| Protein Name | Matrix Metalloproteinase-17Mmp-17Membrane-Type Matrix Metalloproteinase 4Mt-Mmp 4Mtmmp4Membrane-Type-4 Matrix MetalloproteinaseMt4-MmpMt4mmp |
| Database Links | Reactome: R-HSA-1592389 |
| Cellular Localisation | Isoform Long: Cell MembraneLipid-AnchorGpi-AnchorExtracellular SideSecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Matrix Metalloproteinase-17 antibodyAnti-Mmp-17 antibodyAnti-Membrane-Type Matrix Metalloproteinase 4 antibodyAnti-Mt-Mmp 4 antibodyAnti-Mtmmp4 antibodyAnti-Membrane-Type-4 Matrix Metalloproteinase antibodyAnti-Mt4-Mmp antibodyAnti-Mt4mmp antibodyAnti-MMP17 antibodyAnti-MT4MMP antibody |
Information sourced from Uniprot.org