Anti-MMP16 antibody (551-600) (STJ94277)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from human MMP-16. AA range:551-600
General Information
| Short Description | Rabbit polyclonal anti-Matrix metalloproteinase-16 (551-600) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MMP16 |
| Gene ID | 4325 |
| Uniprot ID | MMP16_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MMP-16. AA range:551-600 |
| Immunogen Region | 551-600 |
| Specificity | MMP-16 Polyclonal Antibody detects endogenous levels of MMP-16 protein. |
Additional Info
| Tissue Specificity | Expressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the ovary. |
| Post Translational Modifications | The precursor is cleaved by a furin endopeptidase. |
| Function | Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells. |
| Protein Name | Matrix Metalloproteinase-16Mmp-16Mmp-X2Membrane-Type Matrix Metalloproteinase 3Mt-Mmp 3Mtmmp3Membrane-Type-3 Matrix MetalloproteinaseMt3-MmpMt3mmp |
| Database Links | Reactome: R-HSA-1592389Reactome: R-HSA-9839383 |
| Cellular Localisation | Isoform Long: Cell MembraneSingle-Pass Type I Membrane ProteinExtracellular SideLocalized At The Cell Surface Of Melanoma CellsIsoform Short: SecretedExtracellular SpaceExtracellular MatrixCell Surface |
| Alternative Antibody Names | Anti-Matrix Metalloproteinase-16 antibodyAnti-Mmp-16 antibodyAnti-Mmp-X2 antibodyAnti-Membrane-Type Matrix Metalloproteinase 3 antibodyAnti-Mt-Mmp 3 antibodyAnti-Mtmmp3 antibodyAnti-Membrane-Type-3 Matrix Metalloproteinase antibodyAnti-Mt3-Mmp antibodyAnti-Mt3mmp antibodyAnti-MMP16 antibodyAnti-C8orf57 antibodyAnti-MMPX2 antibody |
Information sourced from Uniprot.org