Anti-MMP14 antibody [R02-6Z2] (STJA0035841)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human MMP14
General Information
| Short Description | Rabbit monoclonal anti-MMP14 for use in WB, IHC-P, ICC, IF, IP and FC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ICC/IF/IP/FC |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R02-6Z2 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200IP 1:50FC 1:50-1:100 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | MMP14 |
| Gene ID | 4323 |
| Uniprot ID | MMP14_HUMAN |
| Immunogen | A synthesized peptide derived from human MMP14 |
Additional Info
| Tissue Specificity | Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors. |
| Post Translational Modifications | The precursor is cleaved by a furin endopeptidase. Tyrosine phosphorylated by PKDCC/VLK. |
| Function | Endopeptidase that degrades various components of the extracellular matrix such as collagen. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. Activates progelatinase A/MMP2, thereby acting as a positive regulator of cell growth and migration. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a regulator of Notch signaling by mediating cleavage and inhibition of DLL1. Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis. Acts as a negative regulator of the GDF15-GFRAL aversive response by mediating cleavage and inactivation of GFRAL. |
| Protein Name | Matrix Metalloproteinase-14Mmp-14Mmp-X1Membrane-Type Matrix Metalloproteinase 1Mt-Mmp 1Mtmmp1Membrane-Type-1 Matrix MetalloproteinaseMt1-MmpMt1mmp |
| Database Links | Reactome: R-HSA-1442490Reactome: R-HSA-1474228Reactome: R-HSA-1592389Reactome: R-HSA-9839383Reactome: R-HSA-9856530 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMelanosomeCytoplasmIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage IvForms A Complex With Bst2 And Localizes To The Cytoplasm |
| Alternative Antibody Names | Anti-Matrix Metalloproteinase-14 antibodyAnti-Mmp-14 antibodyAnti-Mmp-X1 antibodyAnti-Membrane-Type Matrix Metalloproteinase 1 antibodyAnti-Mt-Mmp 1 antibodyAnti-Mtmmp1 antibodyAnti-Membrane-Type-1 Matrix Metalloproteinase antibodyAnti-Mt1-Mmp antibodyAnti-Mt1mmp antibodyAnti-MMP14 antibody |
Information sourced from Uniprot.org