Anti-MMP14 antibody [LEM-2/15] (STJA0019076)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
General Information
| Short Description | Mouse monoclonal Matrix Metalloproteinase-14 antibody for use in Blocking, ELISA, ICC, IF, FC and WB in samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | Blocking/ELISA/ICC/IF/FC/WB |
| Host | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | LEM-2/15 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
Target Information
| Gene Symbol | MMP14 |
| Gene ID | 4323 |
| Uniprot ID | MMP14_HUMAN |
Additional Info
| Post Translational Modifications | The precursor is cleaved by a furin endopeptidase. Tyrosine phosphorylated by PKDCC/VLK. |
| Function | Endopeptidase that degrades various components of the extracellular matrix such as collagen. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. Activates progelatinase A/MMP2, thereby acting as a positive regulator of cell growth and migration. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a regulator of Notch signaling by mediating cleavage and inhibition of DLL1. Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis. Acts as a negative regulator of the GDF15-GFRAL aversive response by mediating cleavage and inactivation of GFRAL. |
| Protein Name | Matrix Metalloproteinase-14Mmp-14Mmp-X1Membrane-Type Matrix Metalloproteinase 1Mt-Mmp 1Mtmmp1Membrane-Type-1 Matrix MetalloproteinaseMt1-MmpMt1mmp |
| Database Links | Reactome: R-HSA-1442490Reactome: R-HSA-1474228Reactome: R-HSA-1592389Reactome: R-HSA-9839383Reactome: R-HSA-9856530 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMelanosomeCytoplasmIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage IvForms A Complex With Bst2 And Localizes To The Cytoplasm |
| Alternative Antibody Names | Anti-Matrix Metalloproteinase-14 antibodyAnti-Mmp-14 antibodyAnti-Mmp-X1 antibodyAnti-Membrane-Type Matrix Metalloproteinase 1 antibodyAnti-Mt-Mmp 1 antibodyAnti-Mtmmp1 antibodyAnti-Membrane-Type-1 Matrix Metalloproteinase antibodyAnti-Mt1-Mmp antibodyAnti-Mt1mmp antibodyAnti-MMP14 antibody |
Information sourced from Uniprot.org