Anti-MMP12 antibody (371-470) [S8MR] (STJ11101938)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal MMP12 (371-470) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S8MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MMP12 |
| Gene ID | 4321 |
| Uniprot ID | MMP12_HUMAN |
| Immunogen Region | 371-470 |
| Immunogen Sequence | FGFPNFVKKIDAAVFNPRFY RTYFFVDNQYWRYDERRQMM DPGYPKLITKNFQGIGPKID AVFYSKNKYYYFFQGSNQFE YDFLLQRITKTLKSNSWFGC |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 371-470 of human MMP12 (P39900). |
Additional Info
| Tissue Specificity | Found in alveolar macrophages but not in peripheral blood monocytes. |
| Function | May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3. |
| Protein Name | Macrophage MetalloelastaseMmeMacrophage ElastaseMeHmeMatrix Metalloproteinase-12Mmp-12 |
| Database Links | Reactome: R-HSA-1442490Reactome: R-HSA-1474228 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Macrophage Metalloelastase antibodyAnti-Mme antibodyAnti-Macrophage Elastase antibodyAnti-Me antibodyAnti-Hme antibodyAnti-Matrix Metalloproteinase-12 antibodyAnti-Mmp-12 antibodyAnti-MMP12 antibodyAnti-HME antibody |
Information sourced from Uniprot.org