Anti-MLF1 antibody [ZN138] (STJA0033377)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenFull length human recombinant prtein of human MLF1 (NP_071888) produced in E.coli.
General Information
| Short Description | Mouse monoclonal anti-MLF1 for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | ZN138 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 0.5-1.0 mg/mL |
| Purification | Affinity Chromatography |
| Dilution Range | IHC 1:50-1:100 |
| Formulation | PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | MLF1 |
| Gene ID | 4291 |
| Uniprot ID | MLF1_HUMAN |
| Immunogen | Full length human recombinant prtein of human MLF1 (NP_071888) produced in E.coli. |
Additional Info
| Tissue Specificity | Most abundant in testis, ovary, skeletal muscle, heart, kidney and colon. Low expression in spleen, thymus and peripheral blood leukocytes. |
| Post Translational Modifications | Phosphorylation is required for binding to YWHAZ. |
| Function | Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. |
| Protein Name | Myeloid Leukemia Factor 1Myelodysplasia-Myeloid Leukemia Factor 1 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusCell ProjectionCiliumCytoskeletonCilium Basal BodyShuttles Between The Cytoplasm And Nucleus |
| Alternative Antibody Names | Anti-Myeloid Leukemia Factor 1 antibodyAnti-Myelodysplasia-Myeloid Leukemia Factor 1 antibodyAnti-MLF1 antibody |
Information sourced from Uniprot.org